For the rome map, I send all my guys to the little house on my side of the river. I play with a team of 1x HPGL, 2x Laser rifle, 1x Sniper rifle (To preserve the armor piercing goodness). I have my 2 laser guys get with full reaction fire on the windows, then my sniper and grenadier get on either side of the door. every turn, my grenadier runs out, shoots a timed grenade to that group of aliens on the bridge closest to the big strip building, and runs back inside. That usually takes care of most of them. Cleanup isn't as easy, though.
For the druglord, I send all my guys to secure that one house. Get one of my laser guys inside the door way, spread my other two around, and get my sniper at the bottom of the stairs. Every turn he goes up, takes a shot, goes back down. The laser trooper in the doorway takes care of any that try and get inside.