In 2.6 the factor for shift speed increase has been raised to 100. For transfers only, not buying. I find this useful for transferring antimatter or alien materials only. In all other cases, it's painful, since I very more often want to transfer or sell/buy a number of items in another category wich is 10, 20, 30 or so.
Before transferring or selling/buying a large number of antimatter or alien materials, restart the game. Makes the mousewheel much faster.