I too started with 10 researchers in my first multifunctional base.
I soon realized after building my second base (with multifunctional intent) that research was taking too long, so I made it a specialized research base.
From that point on my bases were either research, manufacturing or multifunctional depending on location. A research base typically had 50 scientists, and a manufacturing 50 engineers. (it took quite long to recruit so many engineers, but it really paid off nearer the end of the game... thus far anyway)
Something I liked was that bases can be close together - therefore I have a cluster of manufacturing bases built around a ufo storage for stripping down UFOs fast, and for making new ones in tandem.