I've run test builds on XP Home, XP MCE, Vista HP, and Linux (I've got more than one computer and I multiboot them), and I've found that most bugs and issues with running the game (other than compiling) occur regardless of what platform the build is tested on.
If you think an issue you run into could be related to your version of Windows, the most common fixes I know of for Vista to reduce glitches are:
- Disable Areo/transparencies if the video doesn't look right
- Make sure you have the latest drivers from the hardware manufacturers - their own websites, not from Microsoft (Windows Update).