I had this same problem running 2.2.1 on hardy, after some searching of the forums, it appears it is related to the music package, more specifically the lack there off.
Being as I always turn game music off, when I first downloaded 2.2.1, I decided against downloading the music package in synaptic, however, whenever the game got to a mission involving a crashed or landed ufo (ie antarctica, shot down ufo's) any attempt to enter the mission resulted in a game crash, although auto resolve, when available, worked.
I've since downloaded the music package and have not encountered the problem again. Hope this helps.