Just so people know, I have a dual-core desktop that runs this game just fine in Windows MCE without any special tweaks, at 1280x1024, but I have Intel Core CPUs in a Dell XPS, not AMD.
It bombs out with errors if I try to run it under Vista though, although in Vista I didn't try any tweaking yet. (My desktop triple-boots.)
As a side note, I'm currently working on reloading the new Kubuntu Gustsy Beta (Debian-based Linux) on my laptop, and it has intel-based video hardware (I think the front page mentioned this), and I'm curious to see if the game runs under that environment.
EDIT: Forgot to mention, my desktop has an Nvidia video card.